Basic Information
VIS ID
TVIS44018555
Fusion event
HTLV-1-TOMM40L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
161198022/161228232 (Hg38)
End
161198022/161228232 (Hg38)
Orient
-
Location type
Exonic
Target gene
TOMM40L
miRNAs that regulate target gene
hsa-mir-2909 ; hsa-mir-513a-5p ; hsa-mir-1296-5p ; hsa-mir-6508-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-330-3p ; hsa-mir-4512 ; hsa-mir-7160-3p ; hsa-mir-6895-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-let-7a-5p ; hsa-let-7b-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-202-3p ; hsa-mir-3155a ; hsa-mir-3155b ; hsa-mir-3921 ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-4645-5p ; hsa-mir-4649-3p ; hsa-mir-4653-5p ; hsa-mir-4673 ; hsa-mir-4677-3p ; hsa-mir-4679 ; hsa-mir-484 ; hsa-mir-5586-5p ; hsa-mir-7162-3p ; hsa-mir-760 ; hsa-mir-8070 ; hsa-mir-98-5p ; hsa-mir-501-3p ; hsa-mir-502-3p
Nearest miRNA
hsa-mir-101-1/Upstream/971; hsa-mir-1182/Downstream/928875;
Nearest TSS
ENST00000473358/Upstream/348; ENST00000475793/Downstream/198;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/25766, chr1-CpG: 54/Downstream/30455
Upstream sequence
AGGTCTGGATATTGTCTCTATGACTGACTCCATGTCTCCCCATTCCCCCACAGTGATCATGGTTGCTCACTTCCTGCAGAGCCTCACTCATCGGCTGGTG
Downstream sequence
CTGGGAGGAGAGCTAGTTTATCACCGGCGGCCAGGCGAAGAGGGGGCCATCTTGACACTGGCTGGGAAGTACTCGGGTATGGGGCGAAGTGAAGTAGTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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