Basic Information
VIS ID
TVIS44018578
Fusion event
HTLV-1-CEP350 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
180001099/180031964 (Hg38)
End
180001099/180031964 (Hg38)
Orient
+
Location type
Intronic
Target gene
CEP350
miRNAs that regulate target gene
hsa-mir-19b-3p ; hsa-mir-1229-3p ; hsa-mir-19a-3p ; hsa-mir-518a-5p ; hsa-mir-527 ; hsa-mir-616-3p ; hsa-mir-1468-3p ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-548x-5p ; hsa-mir-4289 ; hsa-mir-548aj-5p ; hsa-mir-4698 ; hsa-mir-548aw ; hsa-mir-4426 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-153-3p ; hsa-mir-648 ; hsa-mir-3606-5p ; hsa-mir-3658
Nearest miRNA
hsa-mir-101-1/Upstream/227939; hsa-mir-1182/Downstream/406350;
Nearest TSS
ENST00000473358/Upstream/45782; ENST00000490047/Downstream/9239;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/76680, chr1-CpG: 105/Downstream/122456
Upstream sequence
TAACTCTACTTGAAGTGTTTTCACTGGGCTACCACAAACTATCTCATTTCTTTTGTCTATAAATGTCAATTCTCATCTATTCATCCATTCTTTCAACACA
Downstream sequence
GCTACTTAGCATCCTTATTGTCTTATTGTTTATTTCTTCCTCTCAACTTTTCTGCTGAACTTACTAGACCACTCAGGCAGATTTTGAAATCTCACTCTTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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