Basic Information
VIS ID
TVIS44018582
Fusion event
HTLV-1-APOBEC4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
183620956/183651821 (Hg38)
End
183620956/183651821 (Hg38)
Orient
+
Location type
Intronic
Target gene
APOBEC4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1289 ; hsa-mir-181b-2-3p ; hsa-mir-181b-3p ; hsa-mir-2392 ; hsa-mir-3198 ; hsa-mir-3605-5p ; hsa-mir-4294 ; hsa-mir-4299 ; hsa-mir-4309 ; hsa-mir-4420 ; hsa-mir-4534 ; hsa-mir-5702 ; hsa-mir-6514-5p ; hsa-mir-653-3p ; hsa-mir-8082
Nearest miRNA
hsa-mir-101-1/Upstream/3213431; hsa-mir-1182/Downstream/9064507;
Nearest TSS
ENST00000473358/Upstream/15736; ENST00000360851/Downstream/1492;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/15623, chr1-CpG: 140/Downstream/384404
Upstream sequence
CCTGATGTAACTGAATTCCTGCCTTGAGGCTTCCTAGACCTTGTCATAGCTTTCCTTCTAGAGAGCTGGATTTAACCCTTGGCAGTGGACGATCTCTTGG
Downstream sequence
AACCTGACGCCATTTCCTGCTTACTCCCGAGCATTGTTTCCTCTCTGGACCTCCTCCTTGCTTAGCCTTCATCAGGCTGGATGGATCTCTCCATCAGAAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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