Basic Information
VIS ID
TVIS44018597
Fusion event
HTLV-1-CDA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
20917706/20591213 (Hg38)
End
20917706/20591213 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
CDA
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-12136/Upstream/1694065; hsa-mir-101-1/Downstream/42466;
Nearest TSS
ENST00000473358/Upstream/2127; ENST00000492302/Downstream/42242;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/37211, chr1-CpG: 69/Downstream/42158
Upstream sequence
cggatcacgatgtcaggagatcgagaccatcctggctaacacggtgaaactccatctctactaaaaatacaaaaaaaaatagccgggcgtggtgatgggt
Downstream sequence
gcctgtagtcccagctactcgggaggctgaggcaggagaatggtgtgaacctgggaggcggagcttgcagagagccgagatcgtgccactgcactccagc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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