Basic Information
VIS ID
TVIS44018599
Fusion event
HTLV-1-CD46 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
207942708/207769363 (Hg38)
End
207942708/207769363 (Hg38)
Orient
+
Location type
Intronic
Target gene
CD46
miRNAs that regulate target gene
hsa-mir-520b ; hsa-mir-520e ; hsa-mir-421 ; hsa-mir-548b-3p ; hsa-mir-335-5p ; hsa-mir-340-5p ; hsa-mir-361-5p ; hsa-mir-186-5p ; hsa-mir-181a-5p ; hsa-mir-101-3p ; hsa-mir-98-5p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-652-3p ; hsa-mir-150-3p ; hsa-mir-545-3p ; hsa-mir-3120-3p ; hsa-mir-3121-3p ; hsa-mir-1263 ; hsa-mir-623 ; hsa-mir-4724-3p ; hsa-mir-4670-3p ; hsa-mir-4780 ; hsa-mir-6780b-3p ; hsa-mir-4709-5p ; hsa-mir-4698 ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-3646 ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-4668-5p ; hsa-mir-570-3p ; hsa-mir-4714-3p ; hsa-mir-3925-5p ; hsa-mir-888-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1294499; hsa-mir-1182/Downstream/32489;
Nearest TSS
ENST00000473358/Upstream/1245; ENST00000490278/Downstream/678;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/16744, chr1-CpG: 94/Downstream/99154
Upstream sequence
aaaaCCTTCTTATAATTCCTGTAAGAGCTTGGTAACTGGTAGCCTCCTGAGTTGAGTGCTGTAGGGTTTGAGGGGCAGGAAGAGATGAGTTTTTTAGTGG
Downstream sequence
ACTGATACATGAGCAAAACAAGATTGCATGTGAAATTTATACTCAGTGAGGCATCCGGGCTTAACTCACATGCTCCTAGTGGGTATATGCACTAATACTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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