Basic Information
VIS ID
TVIS44018613
Fusion event
HTLV-1-HSPG2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
22238281/21911788 (Hg38)
End
22238281/21911788 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
HSPG2
miRNAs that regulate target gene
hsa-mir-663a ; hsa-mir-335-5p ; hsa-mir-218-5p ; hsa-mir-1972 ; hsa-mir-346 ; hsa-mir-4266 ; hsa-mir-4294 ; hsa-mir-4459 ; hsa-mir-4536-5p ; hsa-mir-4681 ; hsa-mir-4695-5p ; hsa-mir-4716-3p ; hsa-mir-4723-5p ; hsa-mir-4727-5p ; hsa-mir-4769-3p ; hsa-mir-4779 ; hsa-mir-5698 ; hsa-mir-6511b-5p ; hsa-mir-665 ; hsa-mir-6794-5p ; hsa-mir-6811-5p ; hsa-mir-6817-5p ; hsa-mir-6870-5p ; hsa-mir-7111-5p ; hsa-mir-7154-3p
Nearest miRNA
hsa-mir-12136/Upstream/923356; hsa-mir-101-1/Downstream/354451;
Nearest TSS
ENST00000473358/Upstream/15478; ENST00000374666/Downstream/25509;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/24162, chr1-CpG: 114/Downstream/25065
Upstream sequence
AGGGAGGGAGTCCTGAAGAGGCTTGCAATTTCCCTGGTGCACAGCCCCACTGCAGGCCCTTCAGGAAACGTCCCTGGAGGCTGTGagcttggcccacccc
Downstream sequence
agcccatctcagccccctcagctgccggccagcccagctccactcccagttcggtgccaagcctttccagcccgctccagcccaCGCAGCTCTCTCTCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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