Basic Information
VIS ID
TVIS44018623
Fusion event
HTLV-1-CNIH3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.12
Reference genome
GRCh37/hg19
Start
224761639/224573937 (Hg38)
End
224761639/224573937 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
CNIH3
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-101-1/Upstream/175626; hsa-mir-1182/Downstream/1348143;
Nearest TSS
ENST00000473358/Upstream/8572; ENST00000479227/Downstream/13203;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/216415, chr1-CpG: 156/Downstream/41998
Nearby gene
CNIH3(+42540) ;
Upstream sequence
GAAGGTAATTCACTTGCACGTAGATGCTTTGTAGTTCCTTCCATCTTTTTTTGTAAATGGTATTTCCCTTTTTCATATGTTCTTTTAAAAAAAAGCATTA
Downstream sequence
TATAtttatagagaaagggtctcacagtgttgcccaggctagtcttgaactcctgggctcaaggatcctcccacctcagcctcccaaggtgttgggatta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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