Basic Information
VIS ID
TVIS44018643
Fusion event
HTLV-1-AHCTF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
247078045/246914743 (Hg38)
End
247078045/246914743 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1I
Target gene
AHCTF1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-186-5p
Nearest miRNA
hsa-mir-101-1/Upstream/3568488; hsa-mir-3124/Downstream/287224;
Nearest TSS
ENST00000473358/Upstream/15263; ENST00000474792/Downstream/16620;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/125534, chr1-CpG: 144/Downstream/16440
Upstream sequence
TTTAGAAGACAAAAATAAACATAATGAGTGTATACTGCACCCTACCCAAAAAACAGCTAGTAGGTTGAACTTTTGAAAGTGTCTATCGCTACTCCCCCAT
Downstream sequence
CTTTTCCTTATTCTATATTCTCTCTTCCATACACCAACCATGCATTCAACTGAGCAACCAGTTCAGGAAccttgtttcttctcaattcctcatccaaatg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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