Basic Information
VIS ID
TVIS44018649
Fusion event
HTLV-1-EYA3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p35.3
Reference genome
GRCh37/hg19
Start
28324026/27997515 (Hg38)
End
28324026/27997515 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
EYA3
miRNAs that regulate target gene
hsa-mir-30b-5p ; hsa-let-7c-5p ; hsa-mir-708-5p ; hsa-mir-2467-3p ; hsa-mir-1827 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-6856-5p ; hsa-mir-6758-5p
Nearest miRNA
hsa-mir-12136/Upstream/1442922; hsa-mir-101-1/Downstream/2741641;
Nearest TSS
ENST00000473358/Upstream/33878; ENST00000465645/Downstream/13571;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/37188, chr1-CpG: 23/Downstream/91072
Upstream sequence
GTAGAAGTGATATTACCATCATGACATACTATAAAAAGACCATATACAGTGGCAGGATAATGAAATGCCTTATGGAATCTCTTATGTGTGGGTGATCACT
Downstream sequence
CTCACACCCCTTGCTGTCCAATTCCTCTTAAGACCTGATTCACATCCCAGTCTTCATGAGTTCTGTAACTATCCCATCCCTTGTTTCTACTCCTATCTCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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