Basic Information
VIS ID
TVIS44018659
Fusion event
HTLV-1-PRDM16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.32
Reference genome
GRCh37/hg19
Start
3270432/3353868 (Hg38)
End
3270432/3353868 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
PRDM16
miRNAs that regulate target gene
hsa-mir-133b ; hsa-mir-133a-3p ; hsa-mir-96-5p ; hsa-mir-615-3p ; hsa-mir-346 ; hsa-mir-221-3p ; hsa-mir-101-3p
Nearest miRNA
hsa-mir-12136/Upstream/225833; hsa-mir-101-1/Downstream/206827;
Nearest TSS
ENST00000473358/Upstream/43772; ENST00000606170/Downstream/42623;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/30171, chr1-CpG: 18/Downstream/4597
Nearest cancer related gene
PRDM16(OG, No orient, 0)
Upstream sequence
CCTGACTCCTGCCTCTGTGTCTTGTCACCAGGCCTTACCCTGGGGACCCCTGCTCCCAGCGGAGCCAGTAGTGATGACAGGCGCAGCTGGGAGCAGCTTG
Downstream sequence
GTAGACCTAGGGGGTCTTTCTAGAAGCCAAGGGGGCCCTTGGCACACACATGTGGATGCAGGGCTGCCCACCCAACACTGCTGAGCCCACACAGGCCCAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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