Basic Information
VIS ID
TVIS44018662
Fusion event
HTLV-1-KIAA0319L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
35915286/35449685 (Hg38)
End
35915286/35449685 (Hg38)
Orient
+
Location type
Intronic
Target gene
KIAA0319L
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-423-3p ; hsa-mir-432-5p ; hsa-mir-218-5p ; hsa-mir-5689 ; hsa-mir-571 ; hsa-mir-219a-1-3p ; hsa-mir-129-5p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-431-5p ; hsa-mir-4294 ; hsa-mir-3194-3p ; hsa-mir-924
Nearest miRNA
hsa-mir-12136/Upstream/779991; hsa-mir-101-1/Downstream/1711878;
Nearest TSS
ENST00000473358/Upstream/1486; ENST00000459931/Downstream/321;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/180431, chr1-CpG: 95/Downstream/107394
Upstream sequence
gctctgacacaactgctgtgtgacactgagcaagtcctgccctctctgagtttgtttctccatctgagatgaatagggGGAGGTCTGTATTTCTGCATGG
Downstream sequence
GTAGGAGGTATTATTGGAACAGACGGTCTCTATGGATTTTTCAGCTTGGGGTTTCTCGATTATTTTTAAAGCTGGACATGCCATCTGGCTCTGTCCATGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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