Basic Information
VIS ID
TVIS44018679
Fusion event
HTLV-1-FYB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.2
Reference genome
GRCh37/hg19
Start
57258151/56792478 (Hg38)
End
57258151/56792478 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA1B
Target gene
FYB2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-12136/Upstream/1566755; hsa-mir-101-1/Downstream/2940749;
Nearest TSS
ENST00000473358/Upstream/30465; ENST00000361249/Downstream/26893;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/146914, chr1-CpG: 222/Downstream/629813
Upstream sequence
TTCTCCCAGTTCCAGAGTTTGTTTCTGAAGCTATTGGCCACCATTACTTTTTCCTTAGTGATTATCTCAACATTTGATTGAGTCACCTCTAACAGCAGAG
Downstream sequence
AAGCCTTCTGTGAACTTGTTGCAGAACATACAGTAGACTTTCCCAGAGGCCCTGGGGAGTTAGAACATTTTGGAATTTCACTCTTCTGAGCCAACTTTAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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