Basic Information
VIS ID
TVIS44018687
Fusion event
HTLV-1-PDE4B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
66650871/66185188 (Hg38)
End
66650871/66185188 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
PDE4B
miRNAs that regulate target gene
hsa-mir-374a-5p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-330-5p ; hsa-mir-34a-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1126680; hsa-mir-11399/Downstream/443252;
Nearest TSS
ENST00000473358/Upstream/32798; ENST00000491340/Downstream/72177;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/391953, chr1-CpG: 35/Downstream/347857
Upstream sequence
gtttggtttttttgtccttgcgatagtttgctgagaatgatggtttccagcttcatccatgtccctacaaaggacatgaactcatcgttttttatggctg
Downstream sequence
cgtagtattacatggtgtatatgtgcctcattttcttaatccagtctatcattgttggacatttgggttggttccaaatctttgctattgtgaatagtgc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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