Basic Information
VIS ID
TVIS44018713
Fusion event
HTLV-1-RERE integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.23
Reference genome
GRCh37/hg19
Start
8447848/8387788 (Hg38)
End
8447848/8387788 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
RERE
miRNAs that regulate target gene
hsa-mir-200b-3p ; hsa-mir-429 ; hsa-mir-92b-3p ; hsa-mir-301a-3p ; hsa-mir-320a ; hsa-mir-4681 ; hsa-mir-4722-3p ; hsa-mir-4763-5p ; hsa-mir-4769-3p ; hsa-mir-596 ; hsa-mir-6501-3p ; hsa-mir-6727-3p ; hsa-mir-6817-5p
Nearest miRNA
hsa-mir-12136/Upstream/1957892; hsa-mir-101-1/Downstream/478714;
Nearest TSS
ENST00000473358/Upstream/22950; ENST00000444276/Downstream/35631;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/29298, chr1-CpG: 100/Downstream/35541
Nearest cancer related gene
RERE(OG, No orient, 0)
Upstream sequence
gatgctcaatatgactggaaaccagggaaatacaaattaaaatcactcagacatttcaagtttataatgttggtaagcattttaaggtctgattctatca
Downstream sequence
agtgttggctaggatgtgaagttactggaattcttacatacagctggaaaaacaacaatctgcttttcttggtaaaatagcagatacgcatacctgtaac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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