Basic Information
VIS ID
TVIS44018724
Fusion event
HTLV-1-SPSB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
9391660/9331601 (Hg38)
End
9391660/9331601 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
SPSB1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-425-3p ; hsa-mir-625-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-3202 ; hsa-mir-219b-5p ; hsa-mir-3179 ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-583 ; hsa-mir-8075 ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-567 ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-656-3p ; hsa-mir-1178-5p ; hsa-mir-1233-5p ; hsa-mir-2467-3p ; hsa-mir-30c-1-3p ; hsa-mir-30c-2-3p ; hsa-mir-3678-3p ; hsa-mir-4651 ; hsa-mir-4708-5p ; hsa-mir-4787-5p ; hsa-mir-520g-5p ; hsa-mir-608 ; hsa-mir-6731-5p ; hsa-mir-6752-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6778-5p ; hsa-mir-6788-5p ; hsa-mir-6842-5p ; hsa-mir-6873-5p ; hsa-mir-6878-5p ; hsa-mir-6879-3p ; hsa-mir-7110-5p ; hsa-mir-8085
Nearest miRNA
hsa-mir-12136/Upstream/179824; hsa-mir-101-1/Downstream/635780;
Nearest TSS
ENST00000473358/Upstream/37073; ENST00000377399/Downstream/19830;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/37767, chr1-CpG: 24/Downstream/24466
Upstream sequence
ttgtatttttagtagaaacggggtttcatcatgttgaccaggctggtcttgaactcctgacctcagttgatccactgccttagcctcccaaactgctggg
Downstream sequence
attacaggcgtgagtcaccgtgcctagccGGCACTCATTCTTATGGGCTCACGCACCAGGGGTGGAATTGTTGGATCAGTTGCCATTCATTTCCCCGAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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