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TVIS44018757
Basic Information
VIS ID
TVIS44018757
Fusion event
HTLV-1-EN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
119601944/118844368 (Hg38)
End
119601944/118844368 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
EN1
miRNAs that regulate target gene
hsa-mir-128-2-5p
;
hsa-mir-6781-5p
;
hsa-mir-128-1-5p
;
hsa-mir-4467
;
hsa-mir-139-3p
;
hsa-mir-4746-3p
;
hsa-mir-8072
;
hsa-mir-3960
;
hsa-mir-6746-5p
;
hsa-let-7a-3p
;
hsa-let-7b-3p
;
hsa-let-7f-1-3p
;
hsa-mir-1277-5p
;
hsa-mir-300
;
hsa-mir-3184-5p
;
hsa-mir-381-3p
;
hsa-mir-423-5p
;
hsa-mir-431-3p
;
hsa-mir-4666a-3p
;
hsa-mir-5011-5p
;
hsa-mir-6069
;
hsa-mir-624-3p
;
hsa-mir-98-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/5123000; hsa-mir-10b/Downstream/8579169;
Nearest TSS
ENST00000437798/Upstream/16;
ENST00000412481/Downstream/3310;
Nearest CpG islands
None/Target,
chr2-CpG: 135/Upstream/978
,
chr2-CpG: 198/Downstream/672
Upstream sequence
CCTATGAGCAAAAAGGAGAGGGAGGGAAGCAGGGACAATCCAGAAAAAAAAAAATGTGCTTTGACCACCAGATAGGAATGGGAAGGGGCCACAGGAAACC
Downstream sequence
TCCTTAGGAAGGTGAAGTTCCCCTCAAATACTAGTCTGGGAGGAGGGCCCACTGAGAAAGGAGGGAGGGAAAGCGGGAAAACCAGGAGAGGATTGAACTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Sample Information
×
Sample name
HAM/TSP#2
Sample type
Nontumor
Gender
Female
CpG Island Information
×
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