Basic Information
VIS ID
TVIS44018798
Fusion event
HTLV-1-CD302 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
160653378/159796867 (Hg38)
End
160653378/159796867 (Hg38)
Orient
+
Location type
Intronic
Target gene
CD302
miRNAs that regulate target gene
hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-16-2-3p ; hsa-mir-195-3p ; hsa-mir-3672 ; hsa-mir-4690-3p ; hsa-mir-4786-5p ; hsa-mir-5583-3p ; hsa-mir-5685 ; hsa-mir-6864-3p ; hsa-mir-769-5p
Nearest miRNA
hsa-mir-128-1/Upstream/609966; hsa-mir-10b/Downstream/610943;
Nearest TSS
ENST00000437798/Upstream/37575; ENST00000477952/Downstream/1375;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/83699, chr2-CpG: 69/Downstream/851
Upstream sequence
AAGAAGAGACATACCAAAATCTAGAAACTGATTTTCTTTAAAAGTCTGACAAGAAAGAAAAATCTGACAAGAAAATTCGACTAGCCTAAAGTACAAATGC
Downstream sequence
ACAGCCTCGCAGAGGGTGGTTTACATGAGAGTTGAGATGTTACTGGCTCGCAAAATGAGGGTGTGCAGAAGGAGGGTTCAGAGACAGCCCAGCTTTGTCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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