Basic Information
VIS ID
TVIS44018799
Fusion event
HTLV-1-RBMS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
161261575/160405064 (Hg38)
End
161261575/160405064 (Hg38)
Orient
-
Location type
Intronic
Target gene
RBMS1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-124-3p ; hsa-mir-16-5p ; hsa-mir-1249-3p ; hsa-mir-4662a-5p ; hsa-mir-325 ; hsa-mir-3976 ; hsa-mir-6856-5p ; hsa-mir-6758-5p
Nearest miRNA
hsa-mir-128-1/Upstream/1218163; hsa-mir-10b/Downstream/2746;
Nearest TSS
ENST00000437798/Upstream/37538; ENST00000477952/Downstream/2825;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/134657, chr2-CpG: 104/Downstream/2215
Upstream sequence
gggttcaaatcctggctctgcactttgagttgaatagactttgggcaatttgcttaatctatgcctcagtgttcttaattgtaaaatggatatacaaata
Downstream sequence
ttgcctgcctcacagggcttttaagatgactaaatgagttaatctgccaaaaacattcagaacagcaatcagcaggtagtgaagtactcaatgaaagtta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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