Basic Information
VIS ID
TVIS44018822
Fusion event
HTLV-1-MYO1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
192193587/191328861 (Hg38)
End
192193587/191328861 (Hg38)
Orient
+
Location type
Intronic
Target gene
MYO1B
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-378a-5p ; hsa-mir-363-3p ; hsa-mir-4703-3p ; hsa-mir-145-3p ; hsa-mir-6780b-3p ; hsa-mir-4698 ; hsa-mir-7852-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-3646 ; hsa-mir-561-3p ; hsa-mir-3662
Nearest miRNA
hsa-mir-10b/Upstream/2195750; hsa-mir-1244-1/Downstream/15454373;
Nearest TSS
ENST00000437798/Upstream/51976; ENST00000496992/Downstream/40703;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/82647, chr2-CpG: 88/Downstream/348986
Upstream sequence
caccccacctccatgatgttttggcctttatttttgtctaaaagacatttgtcttgctcattcattctttaggactgagttttccacctcttgagtttct
Downstream sequence
ctgagtccattctccacccctttgaggtttgtcttgttctgccatgttttgcacatacctttatcattgggcttaatgtattggctccattttctctttc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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