Basic Information
VIS ID
TVIS44018825
Fusion event
HTLV-1-ANKRD44 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
197940650/197075926 (Hg38)
End
197940650/197075926 (Hg38)
Orient
+
Location type
Intronic
Target gene
ANKRD44
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-335-3p ; hsa-mir-1277-5p ; hsa-mir-4789-5p ; hsa-mir-190a-3p ; hsa-mir-3941 ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-3171 ; hsa-mir-380-3p ; hsa-mir-383-5p ; hsa-mir-5096 ; hsa-mir-6513-3p ; hsa-mir-129-5p ; hsa-mir-7158-3p ; hsa-mir-4502
Nearest miRNA
hsa-mir-10b/Upstream/7942815; hsa-mir-1244-1/Downstream/9707308;
Nearest TSS
ENST00000437798/Upstream/82288; ENST00000449346/Downstream/12949;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/148643, chr2-CpG: 31/Downstream/88418
Upstream sequence
CGCAGACCAAGCTGAGTGTCAGAGTCAAAGAAAATATACATCAAATTTAATGATACATATTTAATGATATGTATAATCACTGTAATTGCTTGAGTAGACA
Downstream sequence
GGAGGAGGCGCCAAAGACACATTTCATCAGCCTCACAAATCAGCTGGTCCAGATGGCCCCCCATCTTCTTCAATCCTACTCCAGCGCCCAGAGGACAAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate