Basic Information
VIS ID
TVIS44018826
Fusion event
HTLV-1-PLCL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
198879718/198014994 (Hg38)
End
198879718/198014994 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
PLCL1
miRNAs that regulate target gene
hsa-mir-599 ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6844 ; hsa-mir-4775 ; hsa-mir-4778-3p ; hsa-mir-4735-5p ; hsa-mir-3692-3p ; hsa-mir-1236-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-3064-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-130b-5p ; hsa-mir-4727-5p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-140-3p ; hsa-mir-6728-3p ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6873-3p ; hsa-mir-186-3p ; hsa-mir-4714-3p ; hsa-mir-4272 ; hsa-mir-3149 ; hsa-mir-374a-3p ; hsa-mir-361-5p ; hsa-mir-4328 ; hsa-mir-5094 ; hsa-mir-6768-5p
Nearest miRNA
hsa-mir-10b/Upstream/8881883; hsa-mir-1244-1/Downstream/8768240;
Nearest TSS
ENST00000437798/Upstream/204736; ENST00000437704/Downstream/68755;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/209564, chr2-CpG: 315/Downstream/1440785
Upstream sequence
GCTTATTACAGGAATTTTTCCCCCCATATATTTTTGAGCCTCATGCAATTTTGTATAGCAGTAGCCAGTGAAGTTATCCATATTGCTTCCTCTGATATAG
Downstream sequence
TCTCTGAGTCAATTTGTTTTAATGTTTAAAAACTTATTGCCTACTTTTCCTTGACACTTACATGTTCGGCGTTTCAGTGGAAGATAAAATGAAGAAACTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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