VISDB Viral Integration Site DataBase

VIS ID

TVIS44018829

Fusion event

HTLV-1-BMPR2 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr2

Cytoband

q33.1

Reference genome

Start

End

203278750/202414027 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-20a-5p ; hsa-mir-21-5p ; hsa-mir-129-5p ; hsa-mir-92a-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-17-5p ; hsa-mir-100-5p ; hsa-mir-302c-3p ; hsa-mir-130a-3p ; hsa-mir-181c-5p ; hsa-mir-128-3p ; hsa-mir-215-5p ; hsa-mir-7-5p ; hsa-mir-192-5p ; hsa-mir-93-5p ; hsa-mir-26b-5p ; hsa-mir-93-3p ; hsa-mir-135a-5p ; hsa-mir-181a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-32-5p ; hsa-mir-181b-5p ; hsa-mir-181d-5p ; hsa-mir-92b-3p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-548c-3p ; hsa-mir-135b-5p ; hsa-mir-4716-5p ; hsa-mir-4772-3p ; hsa-mir-3615 ; hsa-mir-1304-3p ; hsa-mir-125b-1-3p ; hsa-mir-6890-3p ; hsa-mir-6800-3p ; hsa-mir-6787-3p ; hsa-mir-6736-3p ; hsa-mir-4693-5p ; hsa-mir-103a-2-5p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-550b-3p ; hsa-mir-892c-3p ; hsa-mir-4676-3p ; hsa-mir-452-5p ; hsa-mir-100-3p ; hsa-mir-490-5p ; hsa-mir-153-3p

Nearest miRNA

hsa-mir-10b/Upstream/13280916; hsa-mir-1244-1/Downstream/4369207;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/36332, chr2-CpG: 115/Downstream/220652

Nearest cancer related gene

BMPR2(TSG, No orient, 0)

Upstream sequence

tgctgggattacaggcatgagccaccacgcccaaccttatattattaatatatGTTTCATATATACATATACATACAcaggcataccttgtttattgtgc

Downstream sequence

ttcactattgcacttcacagataactgtgttttgaacaaattgagggtttggggtaactctgcatcaagcaagtcactcaacaccatttttccaacagca