Basic Information
VIS ID
TVIS44018830
Fusion event
HTLV-1-PARD3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
205885239/205020516 (Hg38)
End
205885239/205020516 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
PARD3B
miRNAs that regulate target gene
hsa-mir-6873-3p ; hsa-mir-3941 ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6758-3p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-3180-5p ; hsa-mir-4642 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-891a-3p ; hsa-mir-3688-5p ; hsa-mir-4267
Nearest miRNA
hsa-mir-10b/Upstream/15887405; hsa-mir-1244-1/Downstream/1762718;
Nearest TSS
ENST00000437798/Upstream/55364; ENST00000489565/Downstream/83176;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/474329, chr2-CpG: 91/Downstream/661363
Upstream sequence
AGAAGCATACTAGGTGCTTAGTGCATCTTTGTTGAGTTAAATAAGAGGGTTATTCTTCTGTTCCATCTAAACTCTGCTTGGAATTTCATAAACACAGGCA
Downstream sequence
GGTTCTCACTGGCTTTGGGAAAAAATACCCCTCTTATAAATTCATTAATACAAAGCAAGGGGAAGAGTTGATATTTTAAGTTTACATTCAGGTAAGATTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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