Basic Information
VIS ID
TVIS44018832
Fusion event
HTLV-1-KANSL1L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
GRCh37/hg19
Start
210944728/210080004 (Hg38)
End
210944728/210080004 (Hg38)
Orient
-
Location type
Intronic
Target gene
KANSL1L
miRNAs that regulate target gene
hsa-mir-1277-5p ; hsa-mir-3149 ; hsa-mir-297 ; hsa-mir-675-3p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-5087 ; hsa-mir-511-3p ; hsa-mir-4748 ; hsa-mir-5011-5p ; hsa-mir-4464 ; hsa-mir-574-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-4307 ; hsa-mir-6782-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-3671 ; hsa-mir-607 ; hsa-mir-590-3p
Nearest miRNA
hsa-mir-10b/Upstream/2325123; hsa-mir-1244-1/Downstream/2346259;
Nearest TSS
ENST00000437798/Upstream/49271; ENST00000433296/Downstream/24191;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/77023, chr2-CpG: 99/Downstream/90750
Upstream sequence
AGGAATTAAATAATTGAGGATGGGGAAGTAGTGAGAGTGGGTTTCAGGCTTATacctttctatatttccctggcctcctccctaatccaagctatcttgt
Downstream sequence
accagggttactcaatagccttgaaagtggtctccctcatccacattttcccctctagtcccttctataccaattatttggaaagaacaatctgatcctg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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