Basic Information
VIS ID
TVIS44018851
Fusion event
HTLV-1-HDAC4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
GRCh37/hg19
Start
240287727/239366032 (Hg38)
End
240287727/239366032 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2J
Target gene
HDAC4
miRNAs that regulate target gene
hsa-mir-29b-3p ; hsa-mir-140-5p ; hsa-mir-1-3p ; hsa-mir-22-3p ; hsa-mir-30c-5p ; hsa-mir-302b-3p ; hsa-mir-9-5p ; hsa-mir-206 ; hsa-mir-3149 ; hsa-mir-587 ; hsa-mir-4686 ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-4282 ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-381-3p ; hsa-mir-125a-5p ; hsa-mir-675-5p
Nearest miRNA
hsa-mir-10b/Upstream/14228; hsa-mir-149/Downstream/576983;
Nearest TSS
ENST00000437798/Upstream/56820; ENST00000428471/Downstream/34917;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/90731, chr2-CpG: 263/Downstream/34051
Upstream sequence
GTGGCACTATGTGACATACACAGACATGCATGCACACAGCAGGGTTGTCAGGGTCATGCATGTGGCACTGGTGGACACACACAAACACGCATGCACAGAG
Downstream sequence
CAGGGTCGTCAGGGTCACGCGTGTGGCACTGGCGGACACACACAAACACGCATGCACAGAGCAGGGTCGTCAGGGTCACGCGTGTGGCACTGGCGGACAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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