Basic Information
VIS ID
TVIS44018853
Fusion event
HTLV-1-NDUFA10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
GRCh37/hg19
Start
240851439/239912022 (Hg38)
End
240851439/239912022 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2J
Target gene
NDUFA10
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-let-7b-5p ; hsa-mir-6852-3p ; hsa-mir-3909 ; hsa-mir-767-5p ; hsa-mir-4468 ; hsa-mir-4793-3p ; hsa-mir-3130-3p ; hsa-mir-383-3p ; hsa-mir-6501-3p ; hsa-mir-1226-3p ; hsa-mir-634 ; hsa-mir-6780a-3p
Nearest miRNA
hsa-mir-10b/Upstream/560218; hsa-mir-149/Downstream/30993;
Nearest TSS
ENST00000437798/Upstream/149162; ENST00000426280/Downstream/64563;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/6378, chr2-CpG: 23/Downstream/16839
Nearby gene
MIR4786(-30993) ;
Upstream sequence
agctctgaatctggaacagccctggggggtttcctgggattgtgtacaagggcagctgctgggaccatgcgtctagcaggcaccagctgcatgttgcccc
Downstream sequence
agagaggaggcgcagctttgctcactcgctggaggtacacccctcgtgcccacagaactttctaaaggactcaggcatgaaccatccaaagccaatactc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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