Basic Information
VIS ID
TVIS44018854
Fusion event
HTLV-1-ING5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
GRCh37/hg19
Start
242632447/241693032 (Hg38)
End
242632447/241693032 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2J
Target gene
ING5
miRNAs that regulate target gene
hsa-mir-7157-3p ; hsa-mir-6737-3p ; hsa-mir-5008-3p ; hsa-mir-1914-5p ; hsa-mir-8485 ; hsa-mir-649 ; hsa-mir-6515-5p ; hsa-mir-4443 ; hsa-mir-6827-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-1225-3p ; hsa-mir-432-5p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-6769a-3p ; hsa-mir-331-3p ; hsa-mir-193a-5p
Nearest miRNA
hsa-mir-10b/Upstream/215050;
Nearest TSS
ENST00000437798/Upstream/2618; ENST00000484145/Downstream/9003;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/5727, chr2-CpG: 167/Downstream/8396
Nearby gene
DTYMK(-6064) ;
Nearest cancer related gene
ING5(TSG, No orient, 0)
Upstream sequence
ttggtcctatcacaTTAGgacttcatttaaccttaattagctccttggccaggtgcgttggctcacgcctgtaatctcagcactttgggaggcagaggcg
Downstream sequence
ggcagatcacgagatcaggagctcgagaccagcctggccaacgtggtgaaaccccgtctctactaaatatacacaaattagctgggtgtggtgacgggcg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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