Basic Information
VIS ID
TVIS44018869
Fusion event
HTLV-1-CDC42EP3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
37895889/37668746 (Hg38)
End
37895889/37668746 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDC42EP3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-122-5p ; hsa-mir-218-5p ; hsa-mir-106a-3p ; hsa-mir-129-5p ; hsa-mir-138-2-3p ; hsa-mir-3680-3p ; hsa-mir-4482-3p ; hsa-mir-450b-5p ; hsa-mir-507 ; hsa-mir-557 ; hsa-mir-7159-3p
Nearest miRNA
hsa-mir-1301/Upstream/2197260; hsa-mir-10b/Downstream/9708929;
Nearest TSS
ENST00000437798/Upstream/21088; ENST00000431712/Downstream/3445;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/323492, chr2-CpG: 167/Downstream/2253
Upstream sequence
ACACGCATGTTTAGGTTttgcttactgcacaactttgggtaagttatataactggtctatcctcagtctctacaccagcaaaatggggatacaacggttc
Downstream sequence
tttcattagatgattgctagaaacaagtaagataatcaagacaaaaggctgagaagagtgcttgacacataggacgggctcCACTTAGGAAGTGCTTTTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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