Basic Information
VIS ID
TVIS44018873
Fusion event
HTLV-1-EML4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
42425312/42198172 (Hg38)
End
42425312/42198172 (Hg38)
Orient
-
Location type
Intronic
Target gene
EML4
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-30b-5p ; hsa-mir-16-5p ; hsa-mir-877-3p ; hsa-mir-652-3p ; hsa-mir-148b-3p ; hsa-mir-651-3p ; hsa-mir-551b-5p ; hsa-mir-548c-3p ; hsa-let-7f-2-3p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-142-3p ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-5683 ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-587 ; hsa-mir-377-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-1301/Upstream/6726686; hsa-mir-10b/Downstream/5179503;
Nearest TSS
ENST00000437798/Upstream/27871; ENST00000480320/Downstream/84737;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/28379, chr2-CpG: 61/Downstream/162760
Nearest cancer related gene
EML4(OG, No orient, 0)
Upstream sequence
ctTATCAGTGACTTTACTGGAATTACAGAGACCAGTTTGCTACAGGTTAGGTAGTAATGGAAAAAGAGAATGTCCAAACACCTGTAGCTTGCTCCTACCA
Downstream sequence
GAACTTCTTAAGGGAGATAGAGGGAGTCTGACTTAAAATTGAATTTTTTTTTTCTTTTTTGGTTGGTAGAGATGTGAATATATATTTATCCTGAGGGAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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