Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene514927114991850551225575506585915065941550705608
Basic Information
VIS ID
TVIS44018884
Fusion event
HTLV-1-NRXN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
50932746/50705608 (Hg38)
End
50932746/50705608 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
NRXN1
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-mir-16-5p ; hsa-mir-616-5p ; hsa-mir-498 ; hsa-mir-1537-5p ; hsa-mir-302a-5p ; hsa-mir-3607-3p ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-574-5p ; hsa-mir-4752 ; hsa-mir-6867-5p ; hsa-mir-8056 ; hsa-mir-3691-5p ; hsa-mir-376c-5p ; hsa-mir-376b-5p ; hsa-mir-7114-5p ; hsa-mir-6818-5p ; hsa-mir-4320
Nearest miRNA
hsa-mir-1301/Upstream/9346; hsa-mir-10b/Downstream/1996914;
Nearest TSS
ENST00000437798/Upstream/49194; ENST00000435357/Downstream/207323;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/357929, chr2-CpG: 96/Downstream/321869
Upstream sequence
TCACAAAGAAGTGATCTGGCACTATGAATAAGATATATCTTGACTTTCATAATTTTAGATTACTGGATAATCTCCTGACCAATGCAGTTGGATTATTTCC
Downstream sequence
AACCTCCCACATACAATGTTTTTCTTGAATAATTCAGTGGGAAATAAAGGAGATAAATGAAGTCTCAGAAAATCAGTTGCAGCTTCAACCTCATTTTGAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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