Basic Information
VIS ID
TVIS44018887
Fusion event
HTLV-1-GPR75-ASB3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
54069416/53842279 (Hg38)
End
54069416/53842279 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2D ; FRA2H
Target gene
GPR75-ASB3
miRNAs that regulate target gene
hsa-mir-342-3p ; hsa-mir-1285-5p ; hsa-mir-204-3p ; hsa-mir-2681-5p ; hsa-mir-30a-5p ; hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-4646-5p ; hsa-mir-4747-5p ; hsa-mir-5196-5p ; hsa-mir-7849-3p
Nearest miRNA
hsa-mir-1301/Upstream/1139664; hsa-mir-10b/Downstream/6843;
Nearest TSS
ENST00000437798/Upstream/54669; ENST00000606082/Downstream/17641;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/54918, chr2-CpG: 60/Downstream/17360
Upstream sequence
aatgaactagaagatagggtggacgaagttattcaaactacaacaaagaaagcaagagacgtgctgggcacggtggctcacgcctgtaatcccagcactt
Downstream sequence
tgggaggccaaggcaggtggatcacaaagtcaggagatcaagaccatcctggctaacacggtgaatccccgtctctactaaaaatacaaaaaattagccg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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