Basic Information
VIS ID
TVIS44018898
Fusion event
HTLV-1-USP34 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p15
Reference genome
GRCh37/hg19
Start
61522872/61295737 (Hg38)
End
61522872/61295737 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
USP34
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-23a-3p ; hsa-mir-19b-3p ; hsa-mir-127-5p ; hsa-mir-485-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1301/Upstream/908292; hsa-mir-10b/Downstream/910089;
Nearest TSS
ENST00000437798/Upstream/14586; ENST00000603199/Downstream/5295;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/117511, chr2-CpG: 154/Downstream/174485
Upstream sequence
ttacaactatatatttaaaagtcatacaaatatatgaactcaggaacactgctgttttctactgtcaattcatgaaataatgtaattcacacttaatgtg
Downstream sequence
catctttgaaatgctattactagtgctactgtaagtcatcatttggcattttgaagagcccatcttcttcacttccaagtcttgtgagatattggctctc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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