Basic Information
VIS ID
TVIS44018910
Fusion event
HTLV-1-GCFC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh37/hg19
Start
75893717/75666591 (Hg38)
End
75893717/75666591 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
GCFC2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-155-5p ; hsa-mir-10a-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-1273e ; hsa-mir-6807-5p ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-2467-3p ; hsa-mir-6894-5p ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-605-3p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-3714 ; hsa-mir-1252-5p ; hsa-mir-150-3p ; hsa-mir-4762-3p ; hsa-mir-514a-3p ; hsa-mir-514b-3p ; hsa-mir-532-5p ; hsa-mir-5589-3p ; hsa-mir-5683
Nearest miRNA
hsa-mir-1285-2/Upstream/575677; hsa-mir-10b/Downstream/3982703;
Nearest TSS
ENST00000437798/Upstream/650; ENST00000604464/Downstream/3623;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/19297, chr2-CpG: 64/Downstream/43940
Upstream sequence
TAAGATACAAAGAATGAAAGATAAATTAATTATGTTTTTAATCTTCTATCAGTGTAATACATTGCCTTAATTGTAAAGCAGCAGAATGAATCAATGTAGG
Downstream sequence
TGCATTCAATTTTTCTTTTGGAAATGGAAATTACATTTTATCATTGTCATCCTAAGAGTAATACAAGATTTTGAGAAAAGTTTTGGTAAAAACAGAAAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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