Basic Information
VIS ID
TVIS44018931
Fusion event
HTLV-1-TRABD2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
85071536/84844412 (Hg38)
End
85071536/84844412 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
TRABD2A
miRNAs that regulate target gene
hsa-mir-6809-3p ; hsa-mir-4768-5p ; hsa-mir-6833-3p ; hsa-mir-4753-3p ; hsa-mir-1298-5p ; hsa-mir-130b-5p ; hsa-mir-6739-3p ; hsa-mir-4677-5p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-2117 ; hsa-mir-3124-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-5571-5p ; hsa-mir-659-3p ; hsa-mir-3180-5p ; hsa-mir-202-5p ; hsa-mir-337-3p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-5002-5p ; hsa-mir-10a-3p ; hsa-mir-1270 ; hsa-mir-129-5p ; hsa-mir-2909 ; hsa-mir-296-3p ; hsa-mir-4531 ; hsa-mir-4683 ; hsa-mir-590-3p ; hsa-mir-620 ; hsa-mir-7850-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/4977829; hsa-mir-10b/Downstream/939188;
Nearest TSS
ENST00000437798/Upstream/428; ENST00000233143/Downstream/5144;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/327851, chr2-CpG: 77/Downstream/36195
Upstream sequence
tcgtggttctataaaggggagttcccctgcacacgctctcttgccttccaccatgtaagacacgcctttcctcctccttcaccttccgccatgattgtga
Downstream sequence
ggcctccccaggcaagtggaactgtgagtccattaaacccctttcctttacagattacccagtcttgggtatgtcttcattagcagtgtgagaacagact
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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