Basic Information
VIS ID
TVIS44018936
Fusion event
HTLV-1-EIF2AK3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
88897215/88597697 (Hg38)
End
88897215/88597697 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
EIF2AK3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/515098; hsa-mir-10b/Downstream/214673;
Nearest TSS
ENST00000437798/Upstream/1840; ENST00000453008/Downstream/27232;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/47523, chr2-CpG: 115/Downstream/29022
Upstream sequence
TTGTTCAGTTATGTCATTGTCAATGTCATTTCTTCTTTCTGGAACATCCTTCTGTACCAACTTTGTCCACAGAAATCCTATCTAGCCTTCAACCTAGCAT
Downstream sequence
CATGTATTTTTTTGCTTTGAAATCTAAGAAAATTTTGGCAATGTAAGTTTAGTGACAAAAATCTTCCCATTCCTTAACTTTCCTTTTTGTTGTCACTATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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