Basic Information
VIS ID
TVIS44018940
Fusion event
HTLV-1-MRPS5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
95755442/95089697 (Hg38)
End
95755442/95089697 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
MRPS5
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-320a ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-4635 ; hsa-mir-548l ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548w ; hsa-mir-548y ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/6277243; hsa-mir-10b/Downstream/1708581;
Nearest TSS
ENST00000437798/Upstream/36521; ENST00000611147/Downstream/3994;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/12524, chr2-CpG: 84/Downstream/31647
Upstream sequence
TATGTTAATGTTCATAGTTCCCTACCAACCCAGGCATCAGTCCGAACCACCTACACAGGTAACAGGGAACTGACTGTGCCTGCCCTGTGTGCAGAGGTGC
Downstream sequence
CCTGGGTGCTTCATCCTAGCCCCAACTGAAAGGACTAAATTAGGAAATGAACTTTCTCTTTTGATTTTACTTTTCTATACTGTTGGAGCTTTAGAACAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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