Basic Information
VIS ID
TVIS44018943
Fusion event
HTLV-1-TAF1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
9991319/9851190 (Hg38)
End
9991319/9851190 (Hg38)
Orient
-
Location type
Intronic
Target gene
TAF1B
miRNAs that regulate target gene
hsa-mir-580-3p ; hsa-mir-5189-3p ; hsa-mir-539-5p ; hsa-mir-651-5p ; hsa-mir-4266 ; hsa-mir-24-3p ; hsa-mir-564 ; hsa-mir-383-3p ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-5571-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-2276-3p ; hsa-mir-1304-3p ; hsa-mir-1281 ; hsa-mir-4485-5p ; hsa-mir-6890-3p ; hsa-mir-154-5p ; hsa-mir-4638-5p ; hsa-mir-6741-3p
Nearest miRNA
hsa-mir-7158/Upstream/3200751; hsa-mir-10b/Downstream/341424;
Nearest TSS
ENST00000437798/Upstream/7467; ENST00000492648/Downstream/24808;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/7418, chr2-CpG: 184/Downstream/99588
Upstream sequence
GGTGGAAGCAGTGACTTAGTCCTTTCATTTAGGATTCTGCTGGGCATCGTTCATCATTTAGGATTCTGCTGGGCATTGTTCGGGAAAATAGACATTTTTA
Downstream sequence
AAACTCGTTTCACTTTTTTTTAACATGGTGACTATTCATTTTTCTGCCTCTTAGGTTAATATTTCAGAAAAATACAGATAATGGAAAACATTTGAAATCG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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