Basic Information
VIS ID
TVIS44018958
Fusion event
HTLV-1-HRH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
11205245/11163559 (Hg38)
End
11205245/11163559 (Hg38)
Orient
-
Location type
Intronic
Target gene
HRH1
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-124-3p ; hsa-mir-5089-5p ; hsa-mir-4731-5p ; hsa-mir-5589-5p ; hsa-mir-610 ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-1295b-3p ; hsa-mir-335-3p ; hsa-mir-7977 ; hsa-mir-324-5p ; hsa-mir-665 ; hsa-mir-6833-3p ; hsa-mir-338-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-29a-5p ; hsa-mir-3920 ; hsa-mir-130b-5p ; hsa-mir-4726-3p
Nearest miRNA
hsa-mir-12127/Upstream/768997; hsa-let-7g/Downstream/4332680;
Nearest TSS
ENST00000440867/Upstream/9031; ENST00000413416/Downstream/62472;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/8693, chr3-CpG: 31/Downstream/108644
Upstream sequence
aaacatgggcttggaggctgcaatgagtttgaacccgagctctaccacttagtcactgtatgaccaggagcaagttctgaatttctctgtgcctcagctt
Downstream sequence
cctcatctgtgaaatgggaatgataatagtcctctcccctataaggttgtgaggcctcacccctataaggctaatatgtcaaatgtgctagtccagtgct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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