Basic Information
VIS ID
TVIS44018960
Fusion event
HTLV-1-PHLDB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
111580958/111862111 (Hg38)
End
111580958/111862111 (Hg38)
Orient
+
Location type
Intronic
Target gene
PHLDB2
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-1-3p ; hsa-mir-432-5p ; hsa-mir-376a-5p ; hsa-mir-382-3p ; hsa-mir-29c-3p ; hsa-mir-148a-3p ; hsa-mir-148b-3p ; hsa-mir-152-3p ; hsa-mir-202-5p ; hsa-mir-298 ; hsa-mir-4709-3p
Nearest miRNA
hsa-let-7g/Upstream/2259214; hsa-mir-12124/Downstream/250690;
Nearest TSS
ENST00000440867/Upstream/2315; ENST00000491694/Downstream/21852;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/2219, chr3-CpG: 40/Downstream/116781
Upstream sequence
ttctatttttagtagtgacaggattttgccatgttggtcaggctggtctcaaactcttaacctcaggtgatccacctgccttggcctcccaaagtactgg
Downstream sequence
gattacaggcatgagccaccacacccggtcTCCTTTTAAATATTTTTAAAGGAGTAGTTAACGTTATGGCTTTATATCCTGATTTTCAACCCTTAGCAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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