Basic Information
VIS ID
TVIS44018978
Fusion event
HTLV-1-PARP9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
122258110/122539263 (Hg38)
End
122258110/122539263 (Hg38)
Orient
+
Location type
Intronic
Target gene
PARP9
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-21-5p
Nearest miRNA
hsa-let-7g/Upstream/1489548; hsa-mir-12124/Downstream/622531;
Nearest TSS
ENST00000440867/Upstream/24318; ENST00000383661/Downstream/6740;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/24166, chr3-CpG: 52/Downstream/24892
Upstream sequence
aggccttgcgacaatcttatttcttgacgttttctttctttgcctgacttctacctattatccagttctccatttatgacacctgtgataagcccttccc
Downstream sequence
tgacttcccaagtctgggttaggtgcctctccgcagtgctcccagagcacttttcgctctcctctatcatcactaatctgtgtgctcgtcaaggtccccc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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