VISDB - VIS Detail

Basic Information

VIS ID

TVIS44018980

Fusion event

HTLV-1-SLC49A4 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

29186194

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr3

Cytoband

q21.1

Reference genome

GRCh37/hg19

Start

122600629/122881782 (Hg38)

End

122600629/122881782 (Hg38)

Orient

-

Location type

Intronic

Target gene

SLC49A4

miRNAs that regulate target gene

hsa-mir-320a ; hsa-mir-1178-5p ; hsa-mir-1182 ; hsa-mir-125b-2-3p ; hsa-mir-193a-5p ; hsa-mir-4457 ; hsa-mir-495-5p ; hsa-mir-513b-5p ; hsa-mir-6501-5p

Nearest miRNA

hsa-let-7g/Upstream/1832067; hsa-mir-12124/Downstream/280012;

Nearest TSS

ENST00000440867/Upstream/86698; ENST00000610128/Downstream/5159;

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/86152, chr3-CpG: 100/Downstream/31093

Nearby gene

SLC49A4(+643) ;

Upstream sequence

gatctcagtatgttgcccaggctggactcaaactcctgggctcaagtgatcctcctacctcagccttccgagtagctgggactacaggcatgcaccacca

Downstream sequence

caccaggcTTAATTCTTCTTTTAACACAAAGTAGAATAACACTCTAAAAGTATTACCTAAATGACTAATTAGTTCAAAACATCCCAAGTGGTAGTGATTA

Reference

Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.