Basic Information
VIS ID
TVIS44018991
Fusion event
HTLV-1-RAB7A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
128501182/128782339 (Hg38)
End
128501182/128782339 (Hg38)
Orient
+
Location type
Intronic
Target gene
RAB7A
miRNAs that regulate target gene
hsa-mir-324-3p ; hsa-mir-299-3p ; hsa-mir-6748-5p ; hsa-mir-6759-5p ; hsa-mir-6847-3p ; hsa-mir-6881-5p ; hsa-mir-6835-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-6797-5p ; hsa-mir-3153 ; hsa-mir-1249-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-5681a ; hsa-mir-6783-5p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-4779 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-561-5p ; hsa-mir-6830-5p ; hsa-mir-2355-3p ; hsa-mir-676-3p ; hsa-mir-5590-5p ; hsa-mir-3124-5p ; hsa-mir-6793-5p ; hsa-mir-4437 ; hsa-mir-5580-5p ; hsa-mir-6882-3p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-3607-5p ; hsa-mir-3614-3p
Nearest miRNA
hsa-let-7g/Upstream/1195163; hsa-mir-12124/Downstream/64469;
Nearest TSS
ENST00000440867/Upstream/55987; ENST00000464496/Downstream/12904;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/55532, chr3-CpG: 55/Downstream/96994
Nearest cancer related gene
RAB7A(TSG, No orient, 0)
Upstream sequence
atgactagctatggagccttagacaagttgtgtaaatctcgaattctcagGAAGAAAATGCCATTTGAGCTCTAGCTGAATGGAGAAACACTGCACATGC
Downstream sequence
CAGAACCGTTCTCCCTCATGGTCCATCCAGGCTGATGCCCGCATGGGTGGAGATGCTTGCTGTCTTCCTCCCTGTGCCCTTTTCCCAGCCTCACAAGCAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate