Basic Information
VIS ID
TVIS44019001
Fusion event
HTLV-1-EPHB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
134784032/135065190 (Hg38)
End
134784032/135065190 (Hg38)
Orient
-
Location type
Intronic
Target gene
EPHB1
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-450b-5p ; hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-4279 ; hsa-mir-6868-3p ; hsa-mir-627-3p ; hsa-mir-3124-3p ; hsa-mir-1248 ; hsa-mir-1237-3p
Nearest miRNA
hsa-let-7g/Upstream/627284; hsa-mir-1224/Downstream/16500686;
Nearest TSS
ENST00000440867/Upstream/212684; ENST00000488992/Downstream/2342;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/268052, chr3-CpG: 47/Downstream/900874
Upstream sequence
aaatttattgaggctcattttgtggcctgtcatatggtctatcttggagaaagttccgtgcactgttgaatagaatgtgtattctgcagttgttggatgg
Downstream sequence
aatcttctgtatatatttattaagtccatttgctccaagtgaatagtttaaatccattgtttctttgttgactttctgtcttgatgacctgtctagtgct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate