Basic Information
VIS ID
TVIS44019005
Fusion event
HTLV-1-COPB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
139104805/139385963 (Hg38)
End
139104805/139385963 (Hg38)
Orient
+
Location type
Intronic
Target gene
COPB2
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-mir-376a-5p ; hsa-mir-510-3p ; hsa-mir-8070 ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-549a ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-101-5p ; hsa-mir-8066
Nearest miRNA
hsa-let-7g/Upstream/4948057; hsa-mir-1224/Downstream/12179913;
Nearest TSS
ENST00000440867/Upstream/14167; ENST00000514729/Downstream/3597;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/41659, chr3-CpG: 58/Downstream/3444
Upstream sequence
TTAAAATATATTTCCCCTTCAACAGGTCTTAAACACAACCTAAAAGCTCATTTGGCAAGTTGAGTTACTGTCAAATCTTTATTGCTGTGATCTTCTATGA
Downstream sequence
TGATCATGAATGGGACAGAAATTTAAGGTTACTTTTGAATATAAAAAGAAGATCTAGCAGAGACAACTTCCTGAGACAAAACACCTCACAATGCTTTTAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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