Basic Information
VIS ID
TVIS44019009
Fusion event
HTLV-1-U2SURP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
142728281/143009439 (Hg38)
End
142728281/143009439 (Hg38)
Orient
+
Location type
Intronic
Target gene
U2SURP
miRNAs that regulate target gene
hsa-mir-361-5p ; hsa-mir-29c-3p ; hsa-mir-34a-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-142-5p ; hsa-mir-106b-5p ; hsa-mir-340-5p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-3653-3p ; hsa-mir-4709-5p ; hsa-mir-4711-5p ; hsa-mir-5003-5p ; hsa-mir-5590-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-7112-3p ; hsa-mir-27a-5p ; hsa-mir-185-3p ; hsa-mir-4283 ; hsa-mir-4489 ; hsa-mir-142-3p ; hsa-mir-3529-3p ; hsa-mir-3065-5p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-7161-3p ; hsa-mir-3156-5p ; hsa-mir-548e-5p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-let-7g/Upstream/8571533; hsa-mir-1224/Downstream/8556437;
Nearest TSS
ENST00000440867/Upstream/7211; ENST00000485374/Downstream/2500;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/7522, chr3-CpG: 317/Downstream/109604
Upstream sequence
gtaatcctagcactttcagaggctgaggtggacagatcacctgaggtcaggagttcgagaccagcctggccaacgtggtaaaactccgtctctactaaaa
Downstream sequence
atacaaaaattagccaggcatggtggtgcgtgcctgtactcctagctacccaggaggctgagggaggagaattactggaacccgggaggcggaggctgca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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