Basic Information
VIS ID
TVIS44019023
Fusion event
HTLV-1-PLCH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q25.31
Reference genome
GRCh37/hg19
Start
155204659/155486870 (Hg38)
End
155204659/155486870 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
PLCH1
Nearest miRNA
hsa-let-7g/Upstream/3920875; hsa-mir-1224/Downstream/3795776;
Nearest TSS
ENST00000440867/Upstream/1067; ENST00000476145/Downstream/17702;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/406671, chr3-CpG: 56/Downstream/257258
Upstream sequence
gcctcggcctcccaaagtgctgggattacaggcgtgagccaccgcgcctggccCTGGCTCAAGTTTTAAACAAATTCAGAATGTAATTGTTTCCCTCAAT
Downstream sequence
GTGATAAATGCTAGAGATAATCTGTAGTTAACCTGGGATTCCTAGAATTCAAGAATCATTTTTGAATTATTTACATTTGTGTCTACTTAGATGAGAGGCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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