Basic Information
VIS ID
TVIS44019025
Fusion event
HTLV-1-KCNAB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q25.31
Reference genome
GRCh37/hg19
Start
155955579/156237790 (Hg38)
End
155955579/156237790 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
KCNAB1
miRNAs that regulate target gene
hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-144-5p ; hsa-mir-3613-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-4282 ; hsa-mir-3606-3p
Nearest miRNA
hsa-let-7g/Upstream/4671795; hsa-mir-1224/Downstream/3044856;
Nearest TSS
ENST00000440867/Upstream/9907; ENST00000496923/Downstream/35763;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/365977, chr3-CpG: 29/Downstream/53412
Upstream sequence
tgttttcttaacatttgtgcttcaggttagaggtcacatcctcaaggaggcctttcctgacccctcaatctaaagcttcaccccattttcaaatcattcc
Downstream sequence
tgatcttcttttttacctccgatgtgactttcttaatagtttggtttatttgtttcctgtctgtcttctccaccacagtgcaggtgccatcagaaccagg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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