Basic Information
VIS ID
TVIS44019026
Fusion event
HTLV-1-BTD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
15683322/15641815 (Hg38)
End
15683322/15641815 (Hg38)
Orient
-
Location type
Intronic
Target gene
BTD
miRNAs that regulate target gene
hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-340-5p ; hsa-mir-4729 ; hsa-mir-10b-3p ; hsa-mir-664a-3p ; hsa-mir-6516-5p ; hsa-mir-1273e ; hsa-mir-6499-3p ; hsa-mir-4722-5p ; hsa-mir-2467-3p ; hsa-mir-1827 ; hsa-mir-219b-3p ; hsa-mir-4649-3p ; hsa-mir-1247-3p ; hsa-mir-4768-3p ; hsa-mir-4257 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-302f ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-3942-3p ; hsa-mir-5100 ; hsa-mir-4670-3p ; hsa-mir-6837-3p ; hsa-mir-3620-3p ; hsa-mir-5584-3p ; hsa-mir-148a-5p ; hsa-mir-7160-5p ; hsa-mir-6125 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-570-3p ; hsa-mir-367-5p ; hsa-mir-1267
Nearest miRNA
hsa-mir-12127/Upstream/145507; hsa-let-7g/Downstream/55483;
Nearest TSS
ENST00000440867/Upstream/11813; ENST00000470031/Downstream/34408;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/39741, chr3-CpG: 142/Downstream/217175
Upstream sequence
TCAGGTGGAGTGAGACAGTATCCCCAAGACTAAGATCTCTGAGGAGAGTAAAGACACCATCTCTGTGCCTCTGGTTCCTGCTACAGAGTAACTTCCTGAT
Downstream sequence
GGTTGCCAAAAGAATGAACAGAAGAATGAATGAATGCAGCGGTTCTTCCTGCCATCTGATAACAGACTATTCTTTGATGTTTTCATTTTCAGGATGTACA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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