Basic Information
VIS ID
TVIS44019069
Fusion event
HTLV-1-CCDC50 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q28
Reference genome
GRCh37/hg19
Start
191087173/191369384 (Hg38)
End
191087173/191369384 (Hg38)
Orient
+
Location type
Intronic
Target gene
CCDC50
miRNAs that regulate target gene
hsa-mir-7109-5p ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-7111-5p ; hsa-mir-5698 ; hsa-mir-6870-5p ; hsa-mir-4723-5p ; hsa-mir-3175 ; hsa-mir-6878-5p ; hsa-mir-6133 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4524a-3p ; hsa-mir-6760-5p ; hsa-mir-6856-5p ; hsa-mir-6873-5p ; hsa-mir-6758-5p ; hsa-mir-942-3p ; hsa-mir-4802-3p
Nearest miRNA
hsa-let-7g/Upstream/1539375; hsa-mir-3137/Downstream/3765122;
Nearest TSS
ENST00000440867/Upstream/8281; ENST00000518817/Downstream/56142;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/39463, chr3-CpG: 24/Downstream/493755
Upstream sequence
TACTTTTTTTTTTGAAAAGTTTCTATGAAACTTTTGTGTTCATAAAGGGATGATAATCTTTTAGGAAACATTACGGAATGTTATTCATCATTCTGTCCCT
Downstream sequence
CACAGTGCCTCTCACTTAATGACTGCTAAAAATTTGCCTGGGGATGAACAGGTGGGAGACAGAAGGAAGATTGTTTTCTCTTTTTTGGTTAAGACAGTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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