Basic Information
VIS ID
TVIS44019074
Fusion event
HTLV-1-WDR53 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
196290777/196563906 (Hg38)
End
196290777/196563906 (Hg38)
Orient
-
Location type
Intronic
Target gene
WDR53
miRNAs that regulate target gene
hsa-mir-183-5p ; hsa-mir-5089-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6778-3p ; hsa-mir-4707-3p ; hsa-mir-6506-5p ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-150-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-6504-3p ; hsa-mir-512-3p ; hsa-mir-4438 ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-619-5p
Nearest miRNA
hsa-let-7g/Upstream/681511; hsa-mir-4797/Downstream/729972;
Nearest TSS
ENST00000440867/Upstream/48540; ENST00000440469/Downstream/3404;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/34764, chr3-CpG: 120/Downstream/4564
Upstream sequence
catgatccacccacttcagcctcccaaagtgctgggattataggcgtgcgtcaccgcacccagccTCCCCCTACTTTTAGTCACACATACGATCACTAAT
Downstream sequence
TAGACTGCAAAAAAATCACTGATCTATTAGTAATCAAGGTAACGGAAACGTGATCACAAAATCAAATACAGAAATGTTCATAAAAATAACAAAATAAAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate